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Michael B a Oldstone
Springer

Arenaviruses: Genes, Proteins, and Expression

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AuthorMichael B a Oldstone
PublisherSpringer
PublishedSep 06 2012
Book FormatPaperback
ISBN-139783642716850
Dimensions9.61 X 6.69 X 0.27 inches
Weight 0.48 pounds
BISAC
CategoriesMedical > Immunology
LanguageEnglish

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Book Description

M. B. A. OLDSTONE Viruses are generally studied either because they cause significant human, animal or plant disease or for their utility as materials to probe a basic phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are unusually interesting in that they occupy both of these categories. Arenaviruses cause severe human diseases known primarily as the hemor- rhagic fevers occurring in South and Latin America (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). Because such viruses produce profound disability and may kill the persons they infect, they are a source of economic hardship in the countries where they are prevalent. Further, they provide new problems for health care personnel owing to the narrowing of the world as visitors from many countries increasingly travel to and from these endemic areas. In addition, lymphocytic choriomeningitis virus (LCMV) can infect humans worldwide, although the illness is most often less disabling than those elicited by other arenaviruses. Yet LCMV is likely of greater concern to non-arena-virologists and experimentalists using tissue culture or animals, i. e., workers in molecular biology, cancer research, virology, immunobiology, etc., because normal appearing cultured cells or tissues and animals used for research may be persistently infected with LCMV without manifesting clinical disease or cytopathology and transmit that infection to laboratory workers (reviewed OWSTONE and PETERS 1978). For example, HINMAN et al.

Author Bio

Michael B. A. Oldstone, M.D., is Professor and Head of the Viral-Immunobiology Laboratory at The Scripps Research Institute.

A leader in the field, he has been the recipient of numerous awards and honors and has served or serves on several national and international committees charged with understanding, treating and eliminating viral diseases.

He was a consultant to the World Health Organization for the eradication of poliomyelitis and measles, and was a member of the SAGE Executive Board. He is a member of the National Academy of Sciences.

Education

M.D. (Medicine), University of Maryland, College Park, School of Medicine, 1961
Ph.D. (Biochemistry), Johns Hopkins University, Pratt Institute of Biochemistry, 1959
B.A. (English and History), The University of Alabama (Tuscaloosa), 1954

Source: Scripps Research

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