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Michael B a Oldstone
Springer

HIV and Dementia: Proceedings of the Nimh-Sponsored Conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior

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AuthorMichael B a Oldstone
PublisherSpringer
PublishedSep 07 2012
Book FormatPaperback
ISBN-139783642796593
Dimensions9.21 X 6.14 X 0.63 inches
Weight 0.93 pounds
BISAC
CategoriesMedical > Immunology
LanguageEnglish

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Book Description

The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat- ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor- ders. Death usually occurs within 6 months of the appearance of those more severe symptoms. Up to 90% of children infected with H IV-1 experience attention and concentration difficulties and often experience neurodevelopmental delay or regression over time.

Author Bio

Michael B. A. Oldstone, M.D., is Professor and Head of the Viral-Immunobiology Laboratory at The Scripps Research Institute.

A leader in the field, he has been the recipient of numerous awards and honors and has served or serves on several national and international committees charged with understanding, treating and eliminating viral diseases.

He was a consultant to the World Health Organization for the eradication of poliomyelitis and measles, and was a member of the SAGE Executive Board. He is a member of the National Academy of Sciences.

Education

M.D. (Medicine), University of Maryland, College Park, School of Medicine, 1961
Ph.D. (Biochemistry), Johns Hopkins University, Pratt Institute of Biochemistry, 1959
B.A. (English and History), The University of Alabama (Tuscaloosa), 1954

Source: Scripps Research

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