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Michael B a Oldstone
Springer

Molecular Mimicry: Infection Inducing Autoimmune Disease

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AuthorMichael B a Oldstone
PublisherSpringer
PublishedSep 24 2014
Book FormatPaperback
ISBN-139783642421839
Dimensions9.21 X 6.14 X 0.38 inches
Weight 0.57 pounds
BISAC
CategoriesMedical > Immunology
LanguageEnglish

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Book Description

The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)). Comp- hensive reviews on the pathogenic mechanisms of HTLV-1-associated human diseases are available throughout the medical literature (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Approximately 25 years ago the ?rst human retrovirus, HTLV-1, was isolated (Poeisz et al. 1980). Subsequently, infection with HTLV-1 was shown to cause adult T-cell leukemia (ATL) and HAM/TSP (Gessain et al. 1985; McFarlin and Blattner 1991; Osame et al. 1986; Poeisz et al. 1980; Yoshida et al. 1987). HTLV-1 may infect up to 30% of people in endemic areas and 10 20 million people worldwide (Barmak et al. 2003; Edlich et al. 2000). However, only 1% 5% develop either ATL or HAM/TSP, the remainder being clinically asymptomatic carriers of HTLV-1 (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Why infection with HTLV-1 causes ATL or HAM/TSP in some people while the vast majority of individuals are asymptomatic is largely - known. Some possible factors that may differentiate the asymptomatic from the diseased state include viral strain, human histocompatibility leukocyte antigen (HLA), viral load, and the immune response (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Nagai et al. 1998; Niewiesk et al. 1994; Osame 2002).

Author Bio

Michael B. A. Oldstone, M.D., is Professor and Head of the Viral-Immunobiology Laboratory at The Scripps Research Institute.

A leader in the field, he has been the recipient of numerous awards and honors and has served or serves on several national and international committees charged with understanding, treating and eliminating viral diseases.

He was a consultant to the World Health Organization for the eradication of poliomyelitis and measles, and was a member of the SAGE Executive Board. He is a member of the National Academy of Sciences.

Education

M.D. (Medicine), University of Maryland, College Park, School of Medicine, 1961
Ph.D. (Biochemistry), Johns Hopkins University, Pratt Institute of Biochemistry, 1959
B.A. (English and History), The University of Alabama (Tuscaloosa), 1954

Source: Scripps Research

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